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First published December 20, 2007 as JAMIA PrePrint; doi:10.1197/jamia.M2556
Journal of the American Medical Informatics Association 2008;15(2):130-137
© 2008 American Medical Informatics Association

A more recent version of this article appeared on March 1, 2008
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Submitted on July 13, 2007
Accepted on December 10, 2007

The BRIDG Project: A Technical Report

Douglas B. Fridsma MD, PhD1*, Julie Evans2, Smita Hastak3, and Charles N. Mead MD, MS4

Affiliation of the authors: 1 Arizona State University, Department of Biomedical Informatics, Phoenix, AZ ; 2 Clinical Data Interchange Standards Consortium, Washington DC; 3 ScenPro Inc., Washington DC; 4 Booz Allen Hamilton/National Cancer Institute, Washington DC

* To whom correspondence should be addressed.

Objective The Biomedical Research Integrated Domain Group (BRIDG) project is a collaborative initiative between the National Cancer Institute (NCI), the Clinical Data Interchange Standards Consortium (CDISC), the Regulated Clinical Research Information Management Technical Committee (RCRIM TC) of Health Level 7 (HL7), and the Food and Drug Administration (FDA) to develop a model of the shared understanding of the semantics of clinical research.

Design Principles The BRIDG project is based on open-source collaborative principles and an implementation-independent, use-case driven approach to model development. In the BRIDG model, declarative and procedural knowledge are represented using the Unified Modeling Language (UML) class, activity and state diagrams.

Measured Progress The BRIDG model currently contains harmonized semantics from four project use cases: the caXchange project and the patient study calendar project from caBIGTM; the standard data tabular model (SDTM) from CDISC; and the regulated products submission model (RPS) from HL7. Scalable harmonization processes have been developed to expand the model with content from additional use cases.

Results and Use The first official release of the BRIDG model was published in June 2007. Use of the BRIDG model by the NCI has supported the rapid development of semantic interoperability across applications within the caBIGTM program.

Conclusions The BRIDG project has brought together different standards communities to clarify the semantics of clinical research across pharmaceutical, regulatory, and research organizations. Currently, the NCI uses the BRIDG model to support interoperable application development in the caBIGTM, and CDISC and HL7 are using the BRIDG model to support standards development.






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