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First published February 28, 2008 as JAMIA PrePrint; doi:10.1197/jamia.M2538
Journal of the American Medical Informatics Association 2008;15(3):383-385
© 2008 American Medical Informatics Association

A more recent version of this article appeared on May 1, 2008
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Submitted on June 22, 2007
Accepted on January 16, 2008

Computer-generated automatic alerts of respiratory distress after blood transfusion

Heather Finlay-Morreale BS1, Clifton Louie RPh, DPA2, and Pearl Toy MD3*

Affiliation of the authors: 1 Department of Laboratory Medicine, School of Medicine, University of Cincinnati School of Medicine, Cincinnati, OH ; 2 School of Pharmacy, University of California San Francisco, San Francisco, CA ; 3 Department of Laboratory Medicine, School of Medicine, University of California San Francisco, San Francisco, CA

* To whom correspondence should be addressed.

Transfusion-related acute lung injury (TRALI), the leading cause of transfusion-related death, is underreported by clinicians. For TRALI research, a clinician-independent, computerized system has been developed to detect patients with acute respiratory distress post-transfusion. A computer system generates an alert when a blood gas result indicated a PaO2:FiO2 ratio below 300, within 12 hours of blood issued from the blood bank for a patient. The system was prospectively compared to conventional daily rounds in intensive care units (ICU). We found that ICU rounds detected 9 of 14 patients (64%) while the computer system detected 13 of 14 patients (93%), p=0.125. ICU rounds took 2 to 3 hours a day while the computer system took one to 1.5 hours a day of investigator time. In conclusion, an automatic computer alert system was more efficient, and was as effective as conventional daily ICU rounds, in detecting patients with post-transfusion acute respiratory distress.






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